Certain behavioral and physical symptoms may point to depression and suicide risk. Here's what to look for if you're worried about a friend or family member.

Suicidal Comments

Typical remarks are "I can't go on," "Nothing matters anymore" or even "I'm thinking of ending it all." Says Dr. Leslie Seppinni, a Beverly Hills, Calif., clinical psychologist: "They might make a sudden off-handed comment such as 'If I don't see you in the new year…' and then say they were kidding."

Getting One's Affairs in Order

Making a will or giving away valued possessions. Says Dr. Leslie Seppinni: "They might call their lawyer or accountant to make sure everything is in order."

Drugs and Alcohol

Men are more likely to turn to drugs and alcohol during times of stress than women, although women are quite capable of abusing both when under duress or depressed.

Mood and Behavior Changes

Men are more likely to turn to sex or use prostitutes during times of extreme stress. But women will also have affairs. Behavior might also change: disappearing for periods of time with no good explanation or withdrawing from friends and family.

Passive Suicide

Individuals suffering illnesses that are controlled by prescription drugs--such as hypertension or diabetes--may stop taking their medications or may refuse to go to the doctor.

Losing Weight

Drastic weight loss or changes in appetite, coupled with the individual not appearing healthy, are other signs.

Call for Help

The National Suicide Prevention Lifeline is connected to the U.S. Department of Health and can be reached at 1-800-273-TALK.